Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation

@article{Porokhya2012InotropicEO,
  title={Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation},
  author={M. V. Porokhya and Denis V. Abramochkin and A. A. Abramov and Vladislav S Kuzmin and Galina S. Sukhova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2012},
  volume={153},
  pages={856-858}
}
We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10−5 M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10−4, 3×10−4 M). Sodium hydrosulfide (10−4-4×10−4 M) decreased all the parameters… 

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References

SHOWING 1-10 OF 29 REFERENCES

The Effect of Hydrogen Sulfide on Electrical Activity of Rat Atrial Myocardium

Hydrogen sulfide, recently described as a signal compound, modulates many electrophysiological parameters of the myocardium and is involved in the realization of the effect of hydrogen sulfide on configuration of action potentials.

Cardiac electrophysiological effects of nitric oxide.

The role of NO in the genesis of cardiac arrhythmias during ischemia-reperfusion, heart failure, long QT syndrome, atrial fibrillation, and sudden cardiac death is reviewed.

Positive inotropic effects of carbon monoxide‐releasing molecules (CO‐RMs) in the isolated perfused rat heart

It is investigated whether CO liberated from two water soluble carbon monoxide‐releasing molecules (CO‐RMs) exerts inotropic effects on the myocardium.

Nitric oxide: a trigger for classic preconditioning?

A role for NO (and cGMP) as a trigger in classic PC is suggested, and inhibitors before and during the PC protocol partially attenuated functional recovery, whereas they had no effect when given after the ischemic PC protocol and before sustained ischemia only.

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

Understanding of the cellular and molecular mechanisms that regulate the production and mediate the physiological actions of CO has greatly advanced and many diseases, including neurodegenerations, hypertension, heart failure, and inflammation, have been linked to the abnormality in CO metabolism and function.

Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat.

  • H. LiuD. SongS. S. Lee
  • Biology, Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2001
The enzyme heme oxygenase (HO), which exists in inducible (HO-1) and constitutive (HO-2) isoforms, degrades heme to biliverdin and CO. CO depresses cardiac contraction via cGMP. We aimed to clarify a

Identification of a Long-Lasting Form of Odor Adaptation that Depends on the Carbon Monoxide/cGMP SecondMessenger System

The results indicate that endogenous CO/cGMP signals contribute to olfactory adaptation and underlie the control of gain and sensitivity of odor transduction.