Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation

  title={Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation},
  author={M. V. Porokhya and Denis V. Abramochkin and A. A. Abramov and Vladislav S Kuzmin and Galina S. Sukhova},
  journal={Bulletin of Experimental Biology and Medicine},
  pages={856 - 858}
We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10−5 M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10−4, 3×10−4 M). Sodium hydrosulfide (10−4-4×10−4 M) decreased all the parameters… 

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