Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation

  title={Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation},
  author={M. V. Porokhya and Denis V. Abramochkin and A. A. Abramov and Vladislav S Kuzmin and Galina S. Sukhova},
  journal={Bulletin of Experimental Biology and Medicine},
We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10−5 M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10−4, 3×10−4 M). Sodium hydrosulfide (10−4-4×10−4 M) decreased all the parameters… 

Analysis of decreases in systemic arterial pressure and heart rate in response to the hydrogen sulfide donor sodium sulfide.

The hypotensive and bradycardic effects of H2S can be dissociated, as shown with cardiac pacing experiments, and cardiovascular responses observed in spontaneously hypertensive rats were more robust than those in Sprague-Dawley rats.

Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3β/β-catenin signaling pathway

It is suggested that hydrosulfide exerts cardioprotective effects against AMI-induced apoptosis through the GSK-3β/β-catenin signaling pathway.

Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health

Physiological concentrations of H2S can oppose atherogenesis, ameliorate systemic and pulmonary hypertension, as well as protect the heart subjected to pressure overload, endoplasmic reticulum (ER) stress or adrenergic overstimulation.

Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.

The phosphorodithioate GYY4137 has been proposed as "slow-release" H2S donors and has shown promising efficacy in cellular and animal model diseases such as hypertension, sepsis, atherosclerosis, neonatal lung injury and cancer, however, H 2S generation is inefficient necessitating its use at high concentrations/doses.



The Effect of Hydrogen Sulfide on Electrical Activity of Rat Atrial Myocardium

Hydrogen sulfide, recently described as a signal compound, modulates many electrophysiological parameters of the myocardium and is involved in the realization of the effect of hydrogen sulfide on configuration of action potentials.

Cardiac electrophysiological effects of nitric oxide.

The role of NO in the genesis of cardiac arrhythmias during ischemia-reperfusion, heart failure, long QT syndrome, atrial fibrillation, and sudden cardiac death is reviewed.

Positive inotropic effects of carbon monoxide‐releasing molecules (CO‐RMs) in the isolated perfused rat heart

It is investigated whether CO liberated from two water soluble carbon monoxide‐releasing molecules (CO‐RMs) exerts inotropic effects on the myocardium.

Nitric oxide: a trigger for classic preconditioning?

A role for NO (and cGMP) as a trigger in classic PC is suggested, and inhibitors before and during the PC protocol partially attenuated functional recovery, whereas they had no effect when given after the ischemic PC protocol and before sustained ischemia only.

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

Understanding of the cellular and molecular mechanisms that regulate the production and mediate the physiological actions of CO has greatly advanced and many diseases, including neurodegenerations, hypertension, heart failure, and inflammation, have been linked to the abnormality in CO metabolism and function.

Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat.

  • H. LiuD. SongS. S. Lee
  • Biology, Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2001
The enzyme heme oxygenase (HO), which exists in inducible (HO-1) and constitutive (HO-2) isoforms, degrades heme to biliverdin and CO. CO depresses cardiac contraction via cGMP. We aimed to clarify a

Identification of a Long-Lasting Form of Odor Adaptation that Depends on the Carbon Monoxide/cGMP SecondMessenger System

The results indicate that endogenous CO/cGMP signals contribute to olfactory adaptation and underlie the control of gain and sensitivity of odor transduction.