Inotrophic effects of the K(+) channel blocker TEA on dystrophic (mdx and dy/dy) mouse diaphragm.

Abstract

K(+) channels regulate diaphragm resting membrane potential and action potential duration, and hence force. Certain blockers of these channels, e.g. tetraethylammonium (TEA), increase twitch force of normal diaphragm. To further address whether these agents may be useful in the treatment of diaphragm weakness, studies examined the effects of TEA on force of… (More)

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