Corpus ID: 6325115

Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.

@article{Nomura2008InotodiolAL,
  title={Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.},
  author={Masaaki Nomura and Tatsuo Takahashi and A Uesugi and Reiko Tanaka and Shinjiro Kobayashi},
  journal={Anticancer research},
  year={2008},
  volume={28 5A},
  pages={
          2691-6
        }
}
BACKGROUND To investigate the antitumor effect of Inonotus obliquus Pilat, the antiproliferative effect of lanostane triterpenoids from a chloroform extract of I. obliquus sclerotia against mouse leukemia P388 cells was assessed. MATERIALS AND METHODS Cell viability was measured by MTT assay. Caspase-3/7 activity and DNA fragmentation were evaluated to analyze apoptosis induction. The in vivo antitumor effect was evaluated by the number of survival days of mouse leukemia P388-bearing female… Expand
Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells.
TLDR
The research indicates that inotodiol isolated from Inonotus obliquus inhibited the proliferation of HeLa cells and induced apoptosis in vitro and indicates the potential value of inOTodiol for treatment of human cervical cancer. Expand
Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus.
TLDR
Results indicated that the potential anti-inflammatory effects of inonotusols I and L in microglial BV-2 cells may be imparted through suppression of iNOS, and may support the use of I. obliquus for food and medicinal application. Expand
Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity
Abstract The fungus Inonotus obliquus has historically been used in traditional medicine in Europe and Asia. A melanin fraction and six triterpenoids were obtained from I. obliquus sclerotia, andExpand
Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line.
TLDR
The results can be summarized as, for the mitochondrial apoptotic pathway, quantitative RT-PCR data showed up-regulation of proapoptotic genes (Bax, bad, and caspase-3) and increased Bax/bcl-2 ratio by I. obliquus extracts may be used as a potentially novel food material for health care to improve the treatment of colorectal cancer. Expand
Cytotoxic Activity of Boesenbergia rotunda Extracts against Nasopharyngeal Carcinoma Cells (HK1). Cardamonin, a Boesenbergia rotunda Constituent, Inhibits Growth and Migration of HK1 Cells by Inducing Caspase-Dependent Apoptosis and G2/M–Phase Arrest
TLDR
The cytotoxic activity of Boesenbergia rotunda rhizomes and some of its constituents on nasopharyngeal carcinoma cells (HK1) is investigated to reflect cardamonin’s potential as an anticancer agent. Expand
Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus.
TLDR
Recent findings regarding mechanisms underlying the anticancer influence of Inonotus obliquus are highlighted to provide a comprehensive landscape view of the actions of this mushroom in preventing cancer. Expand
Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells
TLDR
It is hypothesized that the pure compounds separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells in vivo and growth of human carcinoma cells in vitro and that its compounds could be used as natural anticancer ingredients in the food and/or pharmaceutical industry. Expand
Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells.
  • Jiwon Baek, H. Roh, +4 authors Ki Hyun Kim
  • Medicine, Chemistry
  • Journal of ethnopharmacology
  • 2018
TLDR
These findings provide experimental evidence supporting the potential application of I. obliquus in lung cancer treatment and reveal the molecular basis underlying its cytotoxic activity against human lung cancer cells. Expand
In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae).
TLDR
It is concluded that cultivated fruiting body of I. obliquus obtained by inoculation of the substrate with spawn mycelium of the fifth generation could serve as an ideal substitute for the wild I. Obliqueus. Expand
Cytotoxic Evaluation of Compounds Isolated from the Aerial Parts of Hedyotis pilulifera and Methanol Extract of Inonotus obliquus
The aim of this study was to evaluate the inhibitory activity of compounds isolated from the aerial parts of Hedyotis pilulifera (Pit.) T.N. Ninh toward selected cancer cell lines. The isolatedExpand
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References

SHOWING 1-10 OF 20 REFERENCES
Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.
TLDR
Chaga mushroom may provide a new therapeutic option, as a potential anticancer agent, in the treatment of hepatoma, and was accompanied with G0/G1-phase arrest and apoptotic cell death in the cell cycle. Expand
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
TLDR
The most abundant triterpene, inotodiol, was investigated for the inhibitory effect in a two-stage carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter, and was found to exhibit the potent anti-tumor promoting activity in the in vivo carcinogenic test. Expand
In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.
TLDR
The data indicate that the anti-inflammatory and anti-nociceptive properties of MEIO may be due to the inhibition of iNOS and COX-2 expression via the down-regulation of NF-kappaB binding activity. Expand
Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
TLDR
The findings demonstrate that GA-T induced apoptosis of metastatic lung tumor cells through intrinsic pathway related to mitochondrial dysfunction and p53 expression, and it may be a potentially useful chemotherapeutic agent. Expand
Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus.
TLDR
The results indicate that the anti-cancer effect of endo-polysaccharide is not directly tumorcidal but rather is immuno-stimulating. Expand
Antioxidant effect of Inonotus obliquus.
TLDR
The results indicate that Inonotus obliquus has the capacity to scavenge free radicals at concentrations higher than 5 microg/ml and that the polyphenolic extract can protect cells against oxidative stress. Expand
Antimitotic activity of aqueous extracts of Inonotus obliquus.
The cytotoxic effect of two aqueous extracts of Inonotus obliquus on human cervical uteri cancer cells (Hela S3) in vitro was evaluated. It was concluded that Inonotus extracts at a concentration ofExpand
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
TLDR
A new lanostanoid triterpene, 3-oxosulfurenic acid, together with three known triterpenes (3, 4, and 7) were isolated from the fruit bodies of Laetiporus sulphureus and acetyl eburicoic acid was the most potent apoptosis inducer. Expand
Antifungal activity of cysteine, its effect on C-21 oxygenated lanosterol derivatives and other lipids in Inonofus obliquus, in vitro
The antifungal activity of cysteine (2-amino-3-mercaptopropionic acid) on mycelial growth and the production of lanosterol, 3,β-hydroxy-lanosta-8,24-dien-21-al, 3,β-21,dihydroxy-lanosta-8,24-diene,Expand
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.
TLDR
In this investigation for free radical scavengers from the methanolic extract of this mushroom, inonoblins A, B, and C were isolated along with the known compounds, phelligridins D, E, and G, and showed moderate activity against the superoxide radical anion. Expand
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