Inositol trisphosphate receptor Ca2+ release channels.

  title={Inositol trisphosphate receptor Ca2+ release channels.},
  author={J. Kevin Foskett and Carl W. White and King-Ho Cheung and Don-On Daniel Mak},
  journal={Physiological reviews},
  volume={87 2},
The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose… CONTINUE READING
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