Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

@article{Somlyo1985InositolTC,
  title={Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.},
  author={Avril V. Somlyo and Meredith Bond and Andrew P. Somlyo and Antonio Giorgio Scarpa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 15},
  pages={5231-5}
}
Inositol 1,4,5-trisphosphate (InsP3) caused Ca release and tension development in rabbit main pulmonary artery smooth muscle permeabilized with saponin or digitonin. Both of these responses to single additions of InsP3 (0.5-30 microM) were repeatable and occurred in the presence of 0.0-1.9 mM free Mg2+. Sustained contractions were induced by InsP3. The amount of Ca released by InsP3, measured with a Ca2+-selective electrode, was also estimated to be sufficient to stimulate contraction in intact… CONTINUE READING

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