Inositol trisphosphate and calcium signalling mechanisms.

@article{Berridge2009InositolTA,
  title={Inositol trisphosphate and calcium signalling mechanisms.},
  author={Michael John Berridge},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 6},
  pages={
          933-40
        }
}
Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that are coupled to phospholipase C that hydrolyses phosphatidylinosol 4,5-bisphosphate (PIP2) to release IP3 to the cytosol. IP3 receptors located on the endoplasmic reticulum respond to this elevation of IP3 by releasing Ca2+, which is often organized into characteristic spatial (elementary events and… CONTINUE READING
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