Inositol triphosphate produces different patterns of cytoplasmic Ca2+ spiking depending on its concentration.

@article{Petersen1991InositolTP,
  title={Inositol triphosphate produces different patterns of cytoplasmic Ca2+ spiking depending on its concentration.},
  author={Cch Petersen and Emil C. Toescu and Barry V. L. Potter and Ole H Petersen},
  journal={FEBS letters},
  year={1991},
  volume={293 1-2},
  pages={179-82}
}
In single mouse pancreatic acinar cells the effects of intracellular infusion of inositol 1,4,5-trisphosphate (InsP3) or the non-metabolizable InsP3 analogue inositol 1,4,5-triphosphorothioate (InsPS3) have been investigated using a wide range of concentrations. Different types of cytosolic Ca2+ fluctuation patterns (monitored as Ca(2+)-dependent Cl- current in patch-clamp whole-cell recording experiments) could be generated by InsP3 or InsPS3, dependent on concentration, resembling those… CONTINUE READING

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