Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials

@article{Pundir2018InositolTO,
  title={Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials},
  author={Jyotsna Pundir and Dimitrios Psaroudakis and Prakash Savnur and Priya Bhide and Luca Sabatini and Helena J. Teede and Arri Coomarasamy and Shakila Thangaratinam},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2018},
  volume={125},
  pages={299 - 308}
}
Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. Systematic review and meta‐analysis of randomised controlled trials (RCT) that evaluated the effects of inositol as an ovulation induction agent. We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta‐register for RCT and WHO trials’ search portal. We included studies that compared inositol with placebo or… 

Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials.

There was no high-certainty evidence that diets alone in women with PCOS improved health or reproductive outcomes, and Supplementation with vitamin D, probiotics/synbiotics, omega-3, inositol, and curcumin showed favorable effects on some metabolic outcomes.

Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials

Inositol treatment is seriously promising in PCOS, although there is a need for larger studies to clarify optimal regimens, and all results should be reported separately for myoand D-chiro-inositol in any review, without merging all studies in a single average result.

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

The trial sequential analysis of insulin meta-analysis illustrates that the cumulative z-curve crossed the monitoring boundary, providing firm evidence of the intervention effect of MI in improving the metabolic profile of women with PCOS, concomitantly reducing their hyperandrogenism.

Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials

Inositol treatment is seriously promising in PCOS, although there is a need for larger studies to clarify optimal regimens, and all results should be reported separately for myoand D-chiro-inositol in any review, without merging all studies in a single average result.

Efficacy of Myo-inositol on Anthropometric, Metabolic, and Endocrine Outcomes in PCOS Patients: a Meta-analysis of Randomized Controlled Trial

Clinically significant improvement was not observed in anthropometric, metabolic, and endocrine outcomes after myo-inositol treatment in PCOS patients, and heterogeneity between studies was high.

Ovulation induction in polycystic ovary syndrome

A rational order of treatment choices in anovulatory women with polycystic ovary syndrome (PCOS) is suggested, for whom a multitude of treatment options exist, and the importance of weight reduction should be stressed.

Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews

Letrozole appears to be a good first line treatment and gonadotrophins, as a second line treatment, for anovulatory women with PCOS, and further larger scale trials are needed with more precise assessment of treatments according to heterogeneous variants of PCOS.

Infertility management in women with polycystic ovary syndrome: a review

A narrative review was conducted to provide an update and summarize the available evidence on the management of polycystic ovary syndrome related infertility and suggest alternative and adjunctive treatments, like inositol, vitamin D, bariatric surgery and acupuncture.

Inositol for subfertile women with polycystic ovary syndrome.

The evidence for the effectiveness of inositol in subfertile women with a diagnosis of PCOS was of 'low' to 'very low' quality and serious risk of bias due to poor reporting of methods, inconsistency, and lack of reporting of clinically relevant outcomes such as live birth and adverse events.

Overview of systematic reviews of non-pharmacological interventions in women with polycystic ovary syndrome

Lifestyle interventions in women with PCOS appear to improve glycaemic results, androgenic symptoms and anthropometric outcomes, and the role of inositol and N-acetylcysteine in womenWith PCOS needs further evaluation.
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