Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials

@article{Pundir2018InositolTO,
  title={Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials},
  author={Jyotsna Pundir and Dimitrios Psaroudakis and Prakash Savnur and Priya Bhide and Luca Sabatini and Helena J. Teede and Arri Coomarasamy and Shakila Thangaratinam},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2018},
  volume={125},
  pages={299 - 308}
}
Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. Systematic review and meta‐analysis of randomised controlled trials (RCT) that evaluated the effects of inositol as an ovulation induction agent. We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta‐register for RCT and WHO trials’ search portal. We included studies that compared inositol with placebo or… Expand
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials
TLDR
Inositol treatment is seriously promising in PCOS, although there is a need for larger studies to clarify optimal regimens, and all results should be reported separately for myoand D-chiro-inositol in any review, without merging all studies in a single average result. Expand
Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials
TLDR
The trial sequential analysis of insulin meta-analysis illustrates that the cumulative z-curve crossed the monitoring boundary, providing firm evidence of the intervention effect of MI in improving the metabolic profile of women with PCOS, concomitantly reducing their hyperandrogenism. Expand
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials
TLDR
Inositol treatment is seriously promising in PCOS, although there is a need for larger studies to clarify optimal regimens, and all results should be reported separately for myoand D-chiro-inositol in any review, without merging all studies in a single average result. Expand
Ovulation induction in polycystic ovary syndrome
TLDR
A rational order of treatment choices in anovulatory women with polycystic ovary syndrome (PCOS) is suggested, for whom a multitude of treatment options exist, and the importance of weight reduction should be stressed. Expand
Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews
TLDR
Letrozole appears to be a good first line treatment and gonadotrophins, as a second line treatment, for anovulatory women with PCOS, and further larger scale trials are needed with more precise assessment of treatments according to heterogeneous variants of PCOS. Expand
Infertility management in women with polycystic ovary syndrome: a review
TLDR
A narrative review was conducted to provide an update and summarize the available evidence on the management of polycystic ovary syndrome related infertility and suggest alternative and adjunctive treatments, like inositol, vitamin D, bariatric surgery and acupuncture. Expand
Inositol for subfertile women with polycystic ovary syndrome.
TLDR
The evidence for the effectiveness of inositol in subfertile women with a diagnosis of PCOS was of 'low' to 'very low' quality and serious risk of bias due to poor reporting of methods, inconsistency, and lack of reporting of clinically relevant outcomes such as live birth and adverse events. Expand
Overview of systematic reviews of non-pharmacological interventions in women with polycystic ovary syndrome
TLDR
Lifestyle interventions in women with PCOS appear to improve glycaemic results, androgenic symptoms and anthropometric outcomes, and the role of inositol and N-acetylcysteine in womenWith PCOS needs further evaluation. Expand
New prospects of the integrative therapy for polycystic ovary syndrome in women with the disorders of carbohydrate and lipid metabolism: a comparative study
TLDR
To assess the effect of myo- inositol and D-chiro-inositol at a 5:1 ratio on metabolic parameters in women of reproductive age with the second PCOS pathogenetic type and the disorders of carbohydrate and lipid metabolism, 60 overweight and obese women with PCOS were enrolled in this randomized prospective study. Expand
Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials
TLDR
ISLs administration during pregnancy appears to be safe and may represent a novel strategy for GDM prevention, in particular, the double administration of Myo-inositol 2 g per day may improve the glycemic homeostasis and may reduce GDM rate and preterm delivery rate. Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Lifestyle modification programs in polycystic ovary syndrome: systematic review and meta-analysis.
TLDR
The available evidence suggests that LSM reduces fasting blood glucose and insulin levels in women with PCOS and Metformin has similar effects, and translation of these short-term effects to patient-important outcomes, beyond diabetes prevention, remains uncertain. Expand
Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.
TLDR
A beneficial effect of inositol in improving ovarian function in women with oligomenorrhea and polycystic ovaries is found and the inverse relationship between body mass of the patients and the efficacy of the treatment is found. Expand
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials
TLDR
An overview on the clinical outcomes of the MYO use as a treatment to improve ovarian function and metabolic and hormonal parameters in women with PCOS is provided. Expand
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
TLDR
There is no evidence that metformin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clmiphene; therefore, the use of meetformin in improving reproductive outcomes in women with PCOS appears to be limited. Expand
Risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and a meta-analysis.
TLDR
Significant heterogeneity among studies and dependence of the outcome on study type make the higher risk of GDM in women with PCOS a questionable finding. Expand
d-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review
  • N. Galazis, M. Galazi, W. Atiomo
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2011
TLDR
Heterogeneity observed in the methodologies of each study, the scarcity of relevant studies and the small sample sizes used prohibit reliable conclusions to be drawn, therefore, more studies must be conducted in the future to evaluate accurately the effects of DCI in PCOS. Expand
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
TLDR
It is suggested that prevention and treatment of obesity is important for the management of PCOS and central obesity was associated with higher fasting insulin levels. Expand
Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.
TLDR
Data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function and there was an inverse relationship between body mass and treatment efficacy. Expand
Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis
TLDR
Women with PCOS have increased risk of adverse pregnancy and neonatal complications and it is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications. Expand
Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
TLDR
Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors. Expand
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