Inositol pyrophosphates regulate endocytic trafficking.


The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify… (More)


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@article{Saiardi2002InositolPR, title={Inositol pyrophosphates regulate endocytic trafficking.}, author={Adolfo Saiardi and Catherine J. Sciambi and J. Michael McCaffery and Beverly Wendland and Solomon H. Snyder}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2002}, volume={99 22}, pages={14206-11} }