Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.

@article{Ferrn2011InositolP4,
  title={Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.},
  author={Miguel Angel Vilches Ferr{\'o}n and Maya Boudiffa and Michel Arsenault and Mohamed Rached and Monica Pata and Sylvie K Giroux and Latifa Elfassihi and Marina V. Kisseleva and Philip W. Majerus and François Rousseau and Jean Gilles Vacher},
  journal={Cell metabolism},
  year={2011},
  volume={14 4},
  pages={
          466-77
        }
}
Osteoporosis is a multifactorial genetic disease characterized by reduction of bone mass due to dysregulation of osteoclast differentiation or maturation. Herein, we identified a regulator of osteoclastogenesis, the murine homolog of inositol polyphosphate 4-phosphatase type IIα (Inpp4bα). Expression of Inpp4bα is detected from early osteoclast differentiation to activation stage. Targeted expression of native Inpp4bα ex vivo repressed whereas phosphatase-inactive Inpp4bα stimulated osteoclast… CONTINUE READING
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mass in a normal population of French - Canadian women

  • S. Giroux, L. Elfassihi, D. E. C. Cole, F. Rousseau
  • 2008
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