Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine

@article{Kendall1990InositolPH,
  title={Inositol phospholipid hydrolysis in human brain; adenosine inhibition of the response to histamine},
  author={D. Kendall and J. L. Firth},
  journal={British Journal of Pharmacology},
  year={1990},
  volume={100}
}
  • D. Kendall, J. L. Firth
  • Published 1990
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • 1 Inositol phospholipid hydrolysis was examined in human cerebral cortex slices by a [3H]‐inositol prelabelling assay. 2 Enhancement of [3H]‐inositol phosphates accumulation was observed in the presence of carbachol, noradrenaline, histamine, 5‐hydroxytryptamine (5‐HT) and depolarizing concentrations of KCl. 3 Despite having no effect alone, adenosine (and its analogue 2‐chloroadenosine) selectively inhibited the direct response to histamine. 4 The inhibition due to adenosine was antagonized by… CONTINUE READING
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    Direct and indirect stimulations of cyclic AMP formation in human brain
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