Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae.

@article{Cerbn2005InositolPS,
  title={Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae.},
  author={Jorge Cerb{\'o}n and Alejandro Falc{\'o}n and Carlos E Hern{\'a}ndez-Luna and David Segura-Cobos},
  journal={The Biochemical journal},
  year={2005},
  volume={388 Pt 1},
  pages={169-76}
}
We recently reported that DAG (diacylglycerol) generated during sphingomyelin synthesis plays an important role in protein kinase C activation and cell proliferation in Madin-Darby canine kidney cells [Cerbon and Lopez-Sanchez (2003) Biochem. J. 373, 917-924]. In yeast cells, IPC (inositol phosphoceramide) synthase catalyses the transfer of phosphoinositol from phosphatidylinositol to ceramide to form IPC and generates DAG. In the present study, we found that, during the G1 to S transition… CONTINUE READING
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