Inositol phosphates and cell signalling

@article{Berridge1989InositolPA,
  title={Inositol phosphates and cell signalling},
  author={M. Berridge and R. Irvine},
  journal={Nature},
  year={1989},
  volume={341},
  pages={197-205}
}
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second… Expand
3,432 Citations
Inositol trisphosphate and calcium signalling
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