Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium.

@article{Khoo1995InositolPC,
  title={Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium.},
  author={Kian Hoe Khoo and Anne Dell and Howard R. Morris and Patrick Joseph Brennan and Delphi Chatterjee},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 21},
  pages={12380-9}
}
Previous studies have demonstrated that the nonreducing termini of the lipoarabinomannan (LAM) from Mycobacterium tuberculosis are extensively capped with mannose residues, whereas those from a fast growing Mycobacterium sp., once thought to be an attenuated strain of M. tuberculosis, are not. The noncapped LAM, termed AraLAM, is known to be more potent than the mannose-capped LAM (ManLAM) in inducing functions associated with macrophage activation. Using a combination of chemical and enzymatic… CONTINUE READING