Inositol hexasulphate, a casein kinase inhibitor, alters enamel formation in cultured embryonic mouse tooth germs.

@article{TorresQuintana2000InositolHA,
  title={Inositol hexasulphate, a casein kinase inhibitor, alters enamel formation in cultured embryonic mouse tooth germs.},
  author={Mar{\'i}a Ang{\'e}lica Torres-Quintana and Sylvie L{\'e}colle and Dominique Septier and Bruno Palmier and Sheela Sobana Rani and Mary Macdougall and Michel Goldberg},
  journal={Journal of dental research},
  year={2000},
  volume={79 10},
  pages={1794-801}
}
Post-translational modification of enamel proteins is regulated by casein kinases (CK) and results in binding sites for calcium ions that subsequently play a key role during the initial stages of mineralization. Phosphorylation may also influence the secretion and extracellular organization of enamel proteins. Previous studies indicated that inositol hexasulphate inhibited the activity of CK-I and/or CK-II in mouse tooth germs (Torres-Quintana et al., 1998). We hypothesized that inositol… CONTINUE READING