Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.

@article{Nagata2005InositolHK,
  title={Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.},
  author={Eiichiro Nagata and Hongbo Robert Luo and Adolfo Saiardi and Byoung-il Bae and Norihiro Suzuki and Solomon H Snyder},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 2},
  pages={1634-40}
}
Diphosphoinositol pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate contain pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by a family of three inositol hexakisphosphate kinases (InsP6K). In this study we establish one of the InsP6Ks, InsP6K2, as a physiologic mediator of cell death. Overexpression of wild-type InsP6K2 augments the cytotoxic actions of multiple cell stressors in diverse cell lines, whereas transfection with a dominant negative… CONTINUE READING

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