Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.

@article{Yang2001InositolHI,
  title={Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.},
  author={S N Yang and JiaDe Yu and Georg W. Mayr and Franz Hofmann and Olof Flodmark Elna - Marie Larsson and Per Olof Berggren},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 10},
  pages={1753-63}
}
Inositol hexakisphosphate (InsP6) is a most abundant inositol polyphosphate that changes simultaneously with inositol 1,4,5-trisphosphate in depolarized neurons. However, the role of InsP6 in neuronal signaling is unknown. Mass assay reveals that the basal levels of InsP6 in several brain regions tested are similar. InsP6 mass is significantly elevated in activated brain neurons and lowered by inhibition of neuronal activity. Furthermore, the hippocampus is most sensitive to electrical… CONTINUE READING
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