Inositol derivatives: evolution and functions

@article{Michell2008InositolDE,
  title={Inositol derivatives: evolution and functions},
  author={Robert H. Michell},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={151-161}
}
  • R. Michell
  • Published 2008
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
Current research on inositols mainly focuses on myo-inositol (Ins) derivatives in eukaryotic cells, and in particular on the many roles of Ins phospholipids and polyphosphorylated Ins derivatives. However, inositols and their derivatives are more versatile than this — they have acquired diverse functions over the course of evolution. Given the central involvement of primordial bacteria and archaea in the emergence of eukaryotes, what is the status of inositol derivatives in these groups of… Expand

Figures, Tables, and Topics from this paper

Myo -inositol 1-phosphate synthase – the chosen path of evolution
TLDR
The naturally most fit isoform or sequence variety of MIPS, known so far, was identified from the highest evolved plant group angiosperm, and molecular clock analysis confirmed a much higher relative time of divergence from the prokaryotic cyanobacteria to eukaryotes, than the divergence within the eUKaryotic community. Expand
Inositol and its derivatives: their evolution and functions.
  • R. Michell
  • Chemistry, Medicine
  • Advances in enzyme regulation
  • 2011
TLDR
It seems likely that an early member of the Archaea made the first phospholipid with an Ins1P headgroup - maybe three billionyears ago – and that amuchlater archaeal descendent was the ancestral contributor that brought these molecules into the common ancestor of all eukaryotes – maybe two billion years ago. Expand
Inositol pyrophosphates: structure, enzymology and function
TLDR
Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the inositide family and represent a new frontier with both novel targets within the cell and novel modes of action. Expand
Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it
TLDR
The role of inositol acquisition in the biology and pathogenesis of the parasite Leishmania and the fungus Cryptococcus are being explored and the specific strategies used by these pathogens to acquire inotol while in the host are discussed in relation to each pathogen's unique metabolic requirements. Expand
Has Inositol Played Any Role in the Origin of Life?
TLDR
Inositol can be synthesized abiotically and, unlike glucose or ribose, is chemically stable, which makes inositol the ideal candidate for the earliest organophosphate molecules, as primitive inositl phosphates. Expand
Phosphate, inositol and polyphosphates.
TLDR
The intimate links between phosphate, inositol phosphates and polyP are explored, speculating on the evolution of these relationships. Expand
Signalling Properties of Inositol Polyphosphates
TLDR
A review of the intracellular roles of inositol polyphosphates is described and the pharmacological opportunities that modulation of IPs levels can provide are discussed. Expand
The Function of Inositol Phosphatases in Plant Tolerance to Abiotic Stress
TLDR
The general working model might be that inositol phosphatases would degrade the Ins(1,4,5)P3 or phosphoinositides, subsequently resulting in altering Ca2+ release, abscisic acid (ABA) signaling, vesicle trafficking or other cellular processes. Expand
Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5‐bisphosphate faults in human disease
TLDR
The role that recently acquired biochemical and genomic information – especially from archaeons – has played in illuminating the possible evolutionary origins of the biological employment of inositol in lipids, and some questions that these studies raise about the ‘classical’ biosynthetic route to phosphatidylinositol are considered. Expand
Mammalian diseases of phosphatidylinositol transfer proteins and their homologs
TLDR
PITPs are identified to be coincidence detectors, which spatially and temporally coordinate the activities of diverse aspects of the cellular lipid metabolome with phosphoinositide signaling, providing new ideas regarding mechanisms of inherited mammalian diseases associated with derangements in the Activities of PITPs and PITP-like proteins. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 126 REFERENCES
Evolution of the diverse biological roles of inositols.
  • R. Michell
  • Biology, Medicine
  • Biochemical Society symposium
  • 2007
TLDR
Eukaryotes use phosphatidylinositol derivatives for numerous roles in cell signalling and regulation and in protein anchoring at the cell surface, andMulticellular animals and amoebozoans exhibit the greatest variety of functions for PtdIns derivatives, including the use of PTDIns(3,4,5)P3 as a signal. Expand
Inositol pyrophosphates: metabolism and signaling
TLDR
It is suggested that inositol pyrophosphates may represent a class of cellular messengers with basic and not yet fully characterised functions, including vesicular trafficking, apoptosis, telomere maintenance and protein phosphorylation. Expand
Diversification and evolution of L‐myo‐inositol 1‐phosphate synthase 1
TLDR
Analysis by multiple sequence alignment, phylogenetic tree generation and comparison of newly determined crystal structures provides new insight into the origin and evolutionary relationships among the various MIPS proteins/genes. Expand
Phosphatidylinositol biosynthesis: biochemistry and regulation.
TLDR
The impact of regulating PIS1 expression on PI synthesis will be discussed along with the possible role(s) that this may have on diseases such as cancer. Expand
A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
TLDR
A previously uncharacterized class of inositol pyrophosphate synthase is reported and it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes. Expand
Inositol phosphates and cell signaling: new views of InsP5 and InsP6.
TLDR
Interest in the idea that these polyphosphates play more dynamic roles is now increasing, following recent demonstrations that they are precursors of several inositol phosphates that turnover rapidly. Expand
Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium
TLDR
The pathway by which InsP6 is synthesized in the cellular slime mould Dictyostelium, and in cell-free preparations derived from them, is catalysed by a series of soluble ATP-dependent kinases independently of the metabolism of both phosphatidylinositol and Ins(l,4,5)P3. Expand
Inositol phosphates in the environment.
TLDR
Recent advances in technology, such as the development of suitable chromatographic and capillary electrophoresis separation techniques, should help to elucidate some of the more pertinent questions regarding inositol phosphates in the natural environment. Expand
Back in the water: the return of the inositol phosphates
TLDR
Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling. Expand
Biosynthetic Pathways of Inositol and Glycerol Phosphodiesters Used by the Hyperthermophile Archaeoglobus fulgidus in Stress Adaptation
TLDR
The results disclosed here represent an important step toward the elucidation of the regulatory mechanisms underlying the differential accumulation of these compounds in response to heat and osmotic stresses. Expand
...
1
2
3
4
5
...