Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3

@article{Ting2003InositolAF,
  title={Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3},
  author={S. B. Ting and Tomasz Wilanowski and Alana Auden and Mark Hall and Anne Kathrin Voss and Tim Thomas and Vishwas Parekh and John M. Cunningham and Stephen M Jane},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1513-1519}
}
The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation studies that a mouse homolog of the Drosophila grainyhead (grh) gene, grainyhead-like-3 (Grhl3), is a compelling candidate for the gene underlying the curly tail phenotype. The NTDs… CONTINUE READING