Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3

Abstract

The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation studies that a mouse homolog of the… (More)
DOI: 10.1038/nm961

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Cite this paper

@article{Ting2003InositolAF, title={Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3}, author={S. B. Ting and Tomasz Wilanowski and Alana Auden and Mark A. Hall and Anne K. Voss and Tim Thomas and Vishwas Parekh and John M. Cunningham and Stephen M Jane}, journal={Nature Medicine}, year={2003}, volume={9}, pages={1513-1519} }