Inositol Trisphosphate Mediates a RAS-Independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. elegans

@article{Clandinin1998InositolTM,
  title={Inositol Trisphosphate Mediates a RAS-Independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. elegans},
  author={Thomas R Clandinin and John Demodena and Paul W. Sternberg},
  journal={Cell},
  year={1998},
  volume={92},
  pages={523-533}
}
Activity of LET-23, the C. elegans homolog of the epidermal growth factor receptor, is required in multiple tissues. RAS activation is necessary and sufficient for certain LET-23 functions. We show that an inositol trisphosphate receptor can act as a RAS-independent, tissue-specific positive effector of LET-23. Moreover, an inositol trisphosphate kinase negatively regulates this transduction pathway. Signals transduced by LET-23 control ovulation through changes in spermathecal dilation… CONTINUE READING
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Synergistic effects of inositol

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