Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.

@article{Liu2016InositolRequiringE1,
  title={Inositol-Requiring Enzyme 1-Dependent Activation of AMPK Promotes Brucella abortus Intracellular Growth.},
  author={Ning Liu and Yingying Li and Chunyan Dong and Xiao Hu Xu and P. Wei and Wanchun Sun and Qisheng Peng},
  journal={Journal of bacteriology},
  year={2016},
  volume={198 6},
  pages={986-93}
}
UNLABELLED AMP-activated protein kinase (AMPK) is a serine/threonine kinase that is well conserved during evolution. AMPK activation inhibits production of reactive oxygen species (ROS) in cells via suppression of NADPH oxidase. However, the role of AMPK during the process of Brucella infection remains unknown. Our data demonstrate that B. abortus infection induces AMPK activation in HeLa cells in a time-dependent manner. The known AMPK kinases LKB1, CAMKKβ, and TAK1 are not required for the… CONTINUE READING

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