Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2

  title={Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2},
  author={K. Nigorikawa and K. Hazeki and J. Sasaki and Y. Omori and Mikiko Miyake and Shin Morioka and Ying Guo and T. Sasaki and O. Hazeki},
  journal={PLoS ONE},
  • K. Nigorikawa, K. Hazeki, +6 authors O. Hazeki
  • Published 2015
  • Biology, Medicine
  • PLoS ONE
  • Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a) in phagocytosis. Raw264.7 cells that express shRNA against Inpp4a (shInpp4a cells) showed significantly increased phagocytic activity. The introduction of shRNA-resistant human Inpp4a abolished this increase. Macrophages from Inpp4a knockout mice showed similar increases in the phagocytic activity… CONTINUE READING
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