Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors

@article{Su2020InositolAC,
  title={Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors},
  author={Xiang-dong Su and W. Dohle and S. Mills and J. M. Watt and A. M. Rossi and C. Taylor and B. Potter},
  journal={ACS Omega},
  year={2020},
  volume={5},
  pages={28793 - 28811}
}
  • Xiang-dong Su, W. Dohle, +4 authors B. Potter
  • Published 2020
  • Chemistry, Medicine
  • ACS Omega
  • d-myo-Inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP3Rs. A recent synthesis of d-chiro-inositol adenophostin (InsAdA, 5) employed suitably protected chiral building blocks and replaced the d-glucose core by d-chiro-inositol. An alternative approach to fully chiral material is now reported using intrinsic sugar chirality to avoid… CONTINUE READING

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