Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential.

Abstract

ClC Cl(-) channels in endosomes, synaptosomes, lysosomes, and beta-cell insulin granules provide charge neutralization support for the functionally indispensable acidification of the luminal interior by electrogenic H(+)-ATPases (Jentsch, T. J., Stein, V., Weinreich, F., and Zdebik, A. A. (2002) Physiol. Rev. 82, 503-568). Regulation of ClC activity is… (More)

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@article{Renstrm2002Inositol3I, title={Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential.}, author={Erik Renstr{\"o}m and Rosita Ivarsson and Stephen B Shears}, journal={The Journal of biological chemistry}, year={2002}, volume={277 30}, pages={26717-20} }