Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.

@article{Nucifora1996Inositol1R,
  title={Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.},
  author={Frederick Charles Nucifora and Alan H. Sharp and Sharon L. Milgram and Christopher A. Ross},
  journal={Molecular biology of the cell},
  year={1996},
  volume={7 6},
  pages={
          949-60
        }
}
The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular calcium channel involved in coupling cell membrane receptors to calcium signal transduction pathways within cells including endocrine cells. Several isoforms (I, II, and III) of IP3Rs have been identified, which are encoded by separate genes, and are expressed in many tissues with differing patterns of cellular expression. We have generated specific affinity-purified polyclonal anti-peptide antibodies to each of the three… CONTINUE READING
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