Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?

@article{Roderick2013Inositol1R,
  title={Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?},
  author={H Llewelyn Roderick and Bj{\"o}rn C Knollmann},
  journal={Circulation},
  year={2013},
  volume={128 12},
  pages={1273-5}
}
C a 2+ release through ryanodine receptor (RyR) intracel-lular Ca 2+ release channels plays the leading role in the regulation of myocyte contraction. However, Ca 2+ signals arising from their less abundant inositol 1,4,5-trisphosphate (InsP 3)–sensitive counterparts (InsP 3 Rs), also localized to intracellular stores, are emerging as an important modula-tor of Ca 2+-sensitive processes in cardiac myocytes. In this week's issue of Circulation, Signore et al 1 report that activation of InsP 3 R… CONTINUE READING

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