Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?

  title={Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?},
  author={H Llewelyn Roderick and Bj{\"o}rn C Knollmann},
  volume={128 12},
C a 2+ release through ryanodine receptor (RyR) intracel-lular Ca 2+ release channels plays the leading role in the regulation of myocyte contraction. However, Ca 2+ signals arising from their less abundant inositol 1,4,5-trisphosphate (InsP 3)–sensitive counterparts (InsP 3 Rs), also localized to intracellular stores, are emerging as an important modula-tor of Ca 2+-sensitive processes in cardiac myocytes. In this week's issue of Circulation, Signore et al 1 report that activation of InsP 3 R… CONTINUE READING


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Emerging roles of inositol 1 , 4 , 5 - trisphosphate signaling in cardiac myocytes

  • J Kockskämper, AV Zima, HL Roderick, B Pieske, LA Blatter, Bootman
  • J Mol Cell Cardiol
  • 2008

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