Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain.

@article{Worley1989Inositol1R,
  title={Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain.},
  author={Paul F Worley and Jay M Baraban and Solomon H Snyder},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 1},
  pages={339-46}
}
Inositol 1,4,5-trisphosphate is a second messenger generated by stimulation of the phosphoinositide cycle, thought to release calcium from intracellular stores. We have mapped the distribution of 3H-inositol 1,4,5-trisphosphate receptor binding sites in rat brain by autoradiographic techniques. The cerebellum contains the highest level of inositol 1,4,5-trisphosphate binding sites in brain, which appear to be selectively localized to Purkinje cells. Moderate levels of binding sites are present… CONTINUE READING

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