Inositol 1,4,5-trisphosphate-gated channels in cerebellum: presence of multiple conductance states.

@article{Watras1991Inositol1C,
  title={Inositol 1,4,5-trisphosphate-gated channels in cerebellum: presence of multiple conductance states.},
  author={James Watras and Ilya B Bezprozvanny and Barbara E Ehrlich},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 10},
  pages={3239-45}
}
The mechanism by which inositol 1,4,5-triphosphate (InsP3) induces calcium (Ca) release from the reticulum of canine cerebellum was examined. Reticular membrane vesicles used in these experiments accumulated Ca in the presence of ATP and then released approximately 30% of the accumulated Ca upon addition of micromolar concentrations of InsP3. When these membrane vesicles were incorporated into planar lipid bilayers, InsP3-gated Ca channels were observed. Up to four current amplitudes were… CONTINUE READING
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A high affinity receptor for inositol- 1,4,5-trisphosphate purified from bovine cerebellum and reconstituted into planar lipid bilayers forms a ligandactivated Ca*+ -permeable channel

  • S Hingorani, K Ondrias, W Agnew, BE Ehrlich
  • Sot Neurosci Abstr
  • 1990
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