Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.

@article{Prentki1985Inositol1A,
  title={Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.},
  author={Marc Prentki and Barbara E Corkey and Franz M. Matschinsky},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 16},
  pages={9185-90}
}
Regulation of endoplasmic reticulum (ER) Ca2+ cycling by inositol 1,4,5-trisphosphate (IP3) was studied in saponin-permeabilized RINm5F insulinoma cells. Cells were incubated with mitochondrial inhibitors, and medium Ca2+ concentration established by nonmitochondrial pool(s) (presumably the ER) was monitored with a Ca2+ electrode. IP3 degradation accounted… CONTINUE READING