Inositol 1,4,5-trisphosphate and reperfusion arrhythmias.

  title={Inositol 1,4,5-trisphosphate and reperfusion arrhythmias.},
  author={Elizabeth A. Woodcock and Jane F Arthur and Scot J Matkovich},
  journal={Clinical and experimental pharmacology & physiology},
  volume={27 9},
1. The present review focuses on the role of the Ca2+-releasing second messenger inositol 1,4,5-trisphosphate (IP3) in initiating arrhythmias during early reperfusion following a period of myocardial ischaemia. 2. Evidence for an arrhythmogenic action of IP3 was provided by studies showing a correlation between the extent of the increase in IP3 and the… CONTINUE READING