Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

@article{Windhorst2010Inositol13,
  title={Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.},
  author={Sabine Windhorst and Ralf Fliegert and Christine Blechner and Katharina M{\"o}llmann and Zara Hosseini and Thomas G{\"u}nther and Maike Eiben and Lydia Chang and Hong-Ying Lin and Werner Fanick and Udo Schumacher and Burkhard Brandt and Georg W. Mayr},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 8},
  pages={5541-54}
}
Cellular migration is an essential prerequisite for metastatic dissemination of cancer cells. This study demonstrates that the neuron/testis-specific F-actin-targeted inositol 1,4,5-trisphosphate 3-kinase-A (ITPKA) is ectopically expressed in different human tumor cell lines and during tumor progression in the metastatic tumor model Balb-neuT. High expression of ITPKA increases invasive migration in vitro and metastasis in a xenograft SCID mouse model. Mechanistic studies show that ITPKA… CONTINUE READING

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ITPKA Is a Cell Motility-promoting Protein 5554 JOURNAL OF BIOLOGICAL CHEMISTRY

Y. D. Krom, F. J. Fallaux, I. Que, C. Lowik, K. W. van Dijk
BMC Biotechnol • 2006

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