Inositol 1,4,5‐trisphosphate receptors and their protein partners as signalling hubs

  title={Inositol 1,4,5‐trisphosphate receptors and their protein partners as signalling hubs},
  author={David L Prole and Colin W Taylor},
  booktitle={The Journal of physiology},
Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expressed in nearly all animal cells, where they mediate the release of Ca(2+) from intracellular stores. The complex spatial and temporal organization of the ensuing intracellular Ca(2+) signals allows selective regulation of diverse physiological responses. Interactions of IP3 Rs with other proteins contribute to the specificity and speed of Ca(2+) signalling pathways, and to their capacity to integrate information from other signalling… CONTINUE READING


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