Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose-oxygen deprivation.

@article{Haun1996InosineMT,
  title={Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose-oxygen deprivation.},
  author={Steven Edward Haun and J E Segeleon and V L Trapp and Michael A Clotz and Lloyd A. Horrocks},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 5},
  pages={2051-9}
}
Preliminary evidence suggests adenosine, a neuromodulator, has neuroprotective properties during cerebral ischemia. It is unclear, however, if adenosine has glioprotective effects. We studied the effect of adenosine on cellular injury in astroglial cultures subjected to combined glucose-oxygen deprivation. Adenosine (100-1,000 microM)dramatically reduced… CONTINUE READING