Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock.

@article{Hask2000InosineII,
  title={Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock.},
  author={Gy{\"o}rgy Hask{\'o} and David G. Kuhel and Zolt{\'a}n H. N{\'e}meth and Jon G. Mabley and Robert F. Stachlewitz and L{\'a}szl{\'o} Vir{\'a}g and Zoltan Lohinai and Garry J. Southan and Andrew L. Salzman and Csaba Szab{\'o}},
  journal={Journal of immunology},
  year={2000},
  volume={164 2},
  pages={
          1013-9
        }
}
Extracellular purines, including adenosine and ATP, are potent endogenous immunomodulatory molecules. Inosine, a degradation product of these purines, can reach high concentrations in the extracellular space under conditions associated with cellular metabolic stress such as inflammation or ischemia. In the present study, we investigated whether extracellular inosine can affect inflammatory/immune processes. In immunostimulated macrophages and spleen cells, inosine potently inhibited the… CONTINUE READING

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