Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury

@article{Yamagiwa2003InosineAR,
  title={Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury},
  author={Tetsuya Yamagiwa and Tooru Shimosegawa and Akihiko Satoh and Kenji Kimura and Yoshitaka Sakai and Atsushi Masamune},
  journal={Journal of Gastroenterology},
  year={2003},
  volume={39},
  pages={41-49}
}
BackgroundRecent studies have shown that inosine, a purine nucleoside produced during the breakdown of adenosine, has immunomodulatory and anti-inflammatory properties. The aim of this study was to examine the effects of inosine on the course of acute pancreatitis.MethodsEdematous pancreatitis was induced by the intraperitoneal injection of caerulein (50 µg/kg), seven times, at 1-h intervals, in male Wistar rats (caerulein pancreatitis). Inosine (100 mg/kg) was administered 30 min before or 1 h… Expand
Effect of inosine on pancreatitis: a powerful tool?
caerulein pancreatitis, which is a model of mild edematous pancreatitis.5 The study by Yamagiwa et al.,1 reported in this issue of the Journal of Gastroenterology, was performed in the sameExpand
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  • N. E. Bulut, Erkan Özkan, +5 authors G. Şener
  • Chemistry, Medicine
  • Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • 2011
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While plasma amylase, lipase, IL-1ß, and TNF-α levels, and tissue MDA and MPO levels significantly increased in rats with cerulean-induced AP, tissue GSH and Na+-K+-ATPase activity significantly reduced, and changes were reversed and improved with ALA treatment. Expand
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Acute Pancreatitis: Animal Models and Recent Advances in Basic Research
Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and severe inflammation of the pancreas. Patients with AP present with elevated blood and urine levels ofExpand
Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin.
TLDR
The addition of instilled LPS acted as a "second-hit" and exacerbated caerulein-induced AP, compared with the induction of AP alone or the instillation of LPS alone, and could prove useful for examination of therapeutic interventions for ALI following secondary infection. Expand
Visualization, Quantification and Characterization of Caerulein-Induced Acute Pancreatitis in Rats by 3.0T Clinical MRI, Biochemistry and Histomorphology
TLDR
Multiparametric MRI techniques at 3.0T could facilitate noninvasive diagnosis and characterization of Caerulein induced acute pancreatitis in rats, as validated by a novel ex vivo method. Expand
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