Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury

  title={Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury},
  author={Tetsuya Yamagiwa and Tooru Shimosegawa and Akihiko Satoh and Kenji Kimura and Yoshitaka Sakai and Atsushi Masamune},
  journal={Journal of Gastroenterology},
BackgroundRecent studies have shown that inosine, a purine nucleoside produced during the breakdown of adenosine, has immunomodulatory and anti-inflammatory properties. The aim of this study was to examine the effects of inosine on the course of acute pancreatitis.MethodsEdematous pancreatitis was induced by the intraperitoneal injection of caerulein (50 µg/kg), seven times, at 1-h intervals, in male Wistar rats (caerulein pancreatitis). Inosine (100 mg/kg) was administered 30 min before or 1 h… Expand
Effect of inosine on pancreatitis: a powerful tool?
caerulein pancreatitis, which is a model of mild edematous pancreatitis.5 The study by Yamagiwa et al.,1 reported in this issue of the Journal of Gastroenterology, was performed in the sameExpand
Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats.
Results suggest a possible protective role of the carnitine ester in such a murine acute pancreatitis model probably via regulation of the oxidant/antioxidant balance, beside modulation of the myeloperoxidase and nitric oxide systems, which are involved in the inflammatory cascade that most often associate the disease. Expand
AT1 receptor antagonism ameliorates acute pancreatitis-associated pulmonary injury
Losartan treatment can attenuate pancreatic and lung injury and the implication is that a blockade of AT1 receptors may have a clinical application for the treatment of AP and, perhaps more importantly, subsequent pulmonary complications. Expand
Caerulein-induced acute pancreatitis results in mild lung inflammation and altered respiratory mechanics
Caerulein-induced AP results in minor lung injury, which is not sufficient to allow protein permeability and substantially alter respiratory mechanics, and only modest changes were observed in respiratory mechanics. Expand
Montelukast, A Selective Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces Cerulein-Induced Pancreatic Injury in Rats
The results suggest that cysteinyl leukotrienes may be involved in the pathogenesis of acute pancreatitis and that montelukast might be of therapeutic value for treatment of acute Pancreasitis. Expand
Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats.
  • N. E. Bulut, Erkan Özkan, +5 authors G. Şener
  • Chemistry, Medicine
  • Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • 2011
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The potential protective antidiabetic effect of inosine in type 1 diabetic mice
Inosine –a naturally occurring purinewas long considered to be an inactive metabolite of adenosine. However, recently inosine has been shown to be an immunomodulator and anti-inflammatory agent. TheExpand
Acute Pancreatitis: Animal Models and Recent Advances in Basic Research
Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and severe inflammation of the pancreas. Patients with AP present with elevated blood and urine levels ofExpand
Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin.
The addition of instilled LPS acted as a "second-hit" and exacerbated caerulein-induced AP, compared with the induction of AP alone or the instillation of LPS alone, and could prove useful for examination of therapeutic interventions for ALI following secondary infection. Expand
Visualization, Quantification and Characterization of Caerulein-Induced Acute Pancreatitis in Rats by 3.0T Clinical MRI, Biochemistry and Histomorphology
Multiparametric MRI techniques at 3.0T could facilitate noninvasive diagnosis and characterization of Caerulein induced acute pancreatitis in rats, as validated by a novel ex vivo method. Expand


Activation of Adenosine A2a Receptor Pathway Reduces Leukocyte Infiltration but Enhances Edema Formation in Rat Caerulein Pancreatitis
The activation of adenosine A2a receptors modulates the pathology of acute pancreatitis through at least two diverse properties, one is an anti-inflammatory effect involving neutrophils, and the other is a propagating effect for pancreatic edema formation. Expand
Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture.
Inosine reduced systemic inflammation, organ damage, tissue dysoxia, and vascular dysfunction, resulting in improved survival in septic shock and was associated with significant improvement of the survival of CLP mice treated with inosine. Expand
Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.
A role of MIF in the pathogenesis of severe AP is suggested, with serum MIF levels higher in severe AP patients than mild AP patients and healthy controls and anti-MIF antibody treatment improved the survival rate of rats with TCA pancreatitis. Expand
Inosine Exerts a Broad Range of Antiinflammatory Effects in a Murine Model of Acute Lung Injury
Inosine largely suppressed LPS-induced lung inflammation in vivo and reduced the toxicity of cytokines in lung cells in vitro, and support the proposal that inosine might represent a useful adjunct in the therapy of acute respiratory distress syndrome. Expand
Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury.
Treatment with anti-CINC antibody afforded significant protection against pancreatitis associated lung injury, suggesting that CINC plays an important role in the systemic inflammatory response in AP. Expand
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats.
Activation of the adenosine A1-receptor pathway may have an important role in the pathogenesis of acute pancreatitis. Expand
Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody.
It is suggested that TNF-alpha may be an important mediator in the evolution of the systemic manifestations of severe acute pancreatitis. Expand
Inosine reduces inflammation and improves survival in a murine model of colitis.
Inosine protected the colon from DSS-induced inflammatory cell infiltration and lipid peroxidation and partially reduced these parameters in an experimental model of established colitis, suggesting inosine treatment may be a potential therapy in colitis. Expand
Oxidative stress in acute pancreatitis.
To further clarify the role of oxidative stress in acute pancreatitis, an integrated approach is needed, including investigations at various biological levels, from isolated cells or even organelles to laboratory animals and, finally, clinical studies in man. Expand
Pancreatic exocrine secretion in acute experimental pancreatitis.
The present experimental data suggest that pancreatic secretion, and particularly pancreatic secretory response to cholecystokinin, may also be reduced in patients early after the onset of acute pancreatitis. Expand