Inorganic pyrophosphate generation and disposition in pathophysiology.

  title={Inorganic pyrophosphate generation and disposition in pathophysiology.},
  author={Robert A. Terkeltaub},
  journal={American journal of physiology. Cell physiology},
  volume={281 1},
Inorganic pyrophosphate (PP(i)) regulates certain intracellular functions and extracellular crystal deposition. PP(i) is produced, degraded, and transported by specialized mechanisms. Moreover, dysregulated cellular PP(i) production, degradation, and transport all have been associated with disease, and PP(i) appears to directly mediate specific disease manifestations. In addition, natural and synthetic analogs of PP(i) are in use or currently under evaluation as prophylactic agents or therapies… CONTINUE READING

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