• DOI:10.1111/exd.12729
Corpus ID: 22402467

Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes

@article{SimbulanRosenthal2015InorganicPA,
  title={Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes},
  author={C. Simbulan-Rosenthal and Anirudh Gaur and V. A. Sanabria and L. J. Dussan and R. Saxena and J. Schmidt and Takashi Kitani and You-shin Chen and S. Rahim and A. Uren and Elliott Crooke and D. Rosenthal},
  journal={Experimental Dermatology},
  year={2015},
  volume={24}
}

C. Simbulan-Rosenthal, Anirudh Gaur, +9 authors D. Rosenthal

Published 2015

Chemistry, Medicine

Experimental Dermatology

CCL22 in keratinocytes may be an effective target for the treatment of inflammatory skin diseases (7, S2). These preclinical and clinical studies also suggest that TARC/CCL17 and MDC/CCL22 are important molecules involved in the pathogenesis of AD. In this study, crocin exerted an inhibitory effect on PI3K/Akt, ERK1/ 2 and NF-jB activation (8, S3). Pretreatment with crocin clearly suppressed mRNA expression and release of TARC/CCL17 and MDC/CCL22 in TNF-a/IFN-c-stimulated HaCaT cells. NF-jB and… CONTINUE READING

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