Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes

  title={Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes},
  author={C. Simbulan-Rosenthal and Anirudh Gaur and V. A. Sanabria and L. J. Dussan and R. Saxena and J. Schmidt and Takashi Kitani and You-shin Chen and S. Rahim and A. Uren and Elliott Crooke and D. Rosenthal},
  journal={Experimental Dermatology},
  • C. Simbulan-Rosenthal, Anirudh Gaur, +9 authors D. Rosenthal
  • Published 2015
  • Chemistry, Medicine
  • Experimental Dermatology
  • CCL22 in keratinocytes may be an effective target for the treatment of inflammatory skin diseases (7, S2). These preclinical and clinical studies also suggest that TARC/CCL17 and MDC/CCL22 are important molecules involved in the pathogenesis of AD. In this study, crocin exerted an inhibitory effect on PI3K/Akt, ERK1/ 2 and NF-jB activation (8, S3). Pretreatment with crocin clearly suppressed mRNA expression and release of TARC/CCL17 and MDC/CCL22 in TNF-a/IFN-c-stimulated HaCaT cells. NF-jB and… CONTINUE READING
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