Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo.

@article{McInerney2006InorganicPI,
  title={Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo.},
  author={Peter McInerney and Taeko Mizutani and Toshikazu Shiba},
  journal={Molecular microbiology},
  year={2006},
  volume={60 2},
  pages={438-47}
}
Inorganic polyphosphate is a biological macromolecule consisting of multiple phosphates linked by high-energy bonds. Polyphosphate occurs in cells from all domains of life, and is known to play roles in a diverse collection of cellular functions. Here we examine the relationship between polyphosphate and protein synthesis in Escherichia coli. We report that polyphosphate associates with E. coli ribosomes in vitro. Characterization of this interaction reveals that both long-chain and short-chain… CONTINUE READING