Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells

@article{Morimoto2010InorganicPD,
  title={Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells},
  author={Daiki Morimoto and Tetsuya Tomita and Shoko Kuroda and Chikahisa Higuchi and Shinichi Kato and Toshikazu Shiba and Hironori Nakagami and Ryuichi Morishita and Hideki Yoshikawa},
  journal={Journal of Bone and Mineral Metabolism},
  year={2010},
  volume={28},
  pages={418-423}
}
The existence of inorganic polyphosphates [poly(P)] in human cells has been demonstrated. In osteoblasts, it is suggested that the concentration of cellular poly(P) is relatively high. In this study, we examined whether poly(P) accelerates the differentiation of human mesenchymal stem cells (hMSCs) from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) into osteoblastic cells. Alkaline phosphatase (ALP) activity was induced by poly(P) in hMSCs from both OA and RA. In Alizarin Red… CONTINUE READING
12 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Similar Papers

Loading similar papers…