Inorganic phosphate induces spore morphogenesis and enterotoxin production in the intestinal pathogen Clostridium perfringens.

@article{Philippe2006InorganicPI,
  title={Inorganic phosphate induces spore morphogenesis and enterotoxin production in the intestinal pathogen Clostridium perfringens.},
  author={Valeria A Philippe and Marcelo B M{\'e}ndez and I-Hsiu Huang and Lelia M Orsaria and Mahfuzur Rahman Sarker and Roberto Grau},
  journal={Infection and immunity},
  year={2006},
  volume={74 6},
  pages={3651-6}
}
Clostridium perfringens enterotoxin (CPE) is an important virulence factor for food poisoning and non-food borne gastrointestinal (GI) diseases. Although CPE production is strongly regulated by sporulation, the nature of the signal(s) triggering sporulation remains unknown. Here, we demonstrated that inorganic phosphate (Pi), and not pH, constitutes an environmental signal inducing sporulation and CPE synthesis. In the absence of Pi-supplementation, C. perfringens displayed a spo0A phenotype, i… CONTINUE READING
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