Inorganic nitrite therapy: historical perspective and future directions.

  title={Inorganic nitrite therapy: historical perspective and future directions.},
  author={Christopher G. Kevil and Gopi Krishna Kolluru and Christopher B Pattillo and Tony Giordano},
  journal={Free radical biology & medicine},
  volume={51 3},
Over the past several years, investigators studying nitric oxide (NO) biology and metabolism have come to learn that the one-electron oxidation product of NO, nitrite anion, serves as a unique player in modulating tissue NO bioavailability. Numerous studies have examined how this oxidized metabolite of NO can act as a salvage pathway for maintaining NO equivalents through multiple reduction mechanisms in permissive tissue environments. Moreover, it is now clear that nitrite anion production and… CONTINUE READING


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