Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells.

@article{Poulin1995InorganicCD,
  title={Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells.},
  author={Richard Poulin and M Lessard and Changqing Zhao},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 4},
  pages={1695-704}
}
The mechanism of polyamine uptake in mammalian cells is still poorly understood. The role of inorganic cations in polyamine transport was investigated in ZR-75-1 human breast cancer cells. Although strongly temperature dependent, neither putrescine nor spermidine uptake was mediated by a Na+ cotransport mechanism. In fact, Na+ and cholinium competitively inhibited putrescine uptake relative to that measured in a sucrose-based medium. On the other hand, ouabain, H+, Na+, and Ca2+ ionophores, as… CONTINUE READING

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