Inorganic cadmium increases the frequency of chemically induced chromosome aberrations in cultured mammalian cells.

@article{Yamada1993InorganicCI,
  title={Inorganic cadmium increases the frequency of chemically induced chromosome aberrations in cultured mammalian cells.},
  author={Hisami Yamada and Tatsuro Miyahara and Yu F Sasaki},
  journal={Mutation research},
  year={1993},
  volume={302 3},
  pages={137-45}
}
The co-clastogenic effect of cadmium ion (Cd2+) was studied in Chinese hamster CHO K1 cells and excision repair-deficient human XP20SSV cells. Cd2+ at < or = 28.0 microM did not show any clastogenic effects under the experimental conditions used. Cd2+ post-treatment at < or = 3.50 microM, however, increased the number of both breakage- and exchange-type chromatid aberrations induced by mitomycin C (MMC) and 4-nitroquinoline 1-oxide (4NQO) in CHO K1 cells. Enhancement of chromosome aberrations… CONTINUE READING

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