Inorganic arsenite-induced malignant transformation of human prostate epithelial cells.

@article{Achanzar2002InorganicAM,
  title={Inorganic arsenite-induced malignant transformation of human prostate epithelial cells.},
  author={William E Achanzar and Eduardo M Brambila and Bhalchandra A. Diwan and Mukta M. Webber and Michael P. Waalkes},
  journal={Journal of the National Cancer Institute},
  year={2002},
  volume={94 24},
  pages={1888-91}
}
Although several epidemiologic studies show an association between arsenic exposure and prostate cancer, it is still unknown whether human prostate epithelial cells are directly susceptible to arsenic-induced transformation. This study was designed to determine whether the nontumorigenic human prostate epithelial cell line RWPE-1 could be malignantly transformed in vitro by arsenite. RWPE-1 cells were continuously exposed to 5 micro M arsenite and monitored for signs of transformation, assessed… CONTINUE READING

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