Inorganic Polyphosphate Induces Osteoblastic Differentiation

  title={Inorganic Polyphosphate Induces Osteoblastic Differentiation},
  author={Y Usui and T Uematsu and Takayuki Uchihashi and M Takahashi and Masahide Ishizuka and Ryosuke Doto and H. Tanaka and Yusuke Komazaki and M. Osawa and K. Yamada and Minoru Yamaoka and Kiyofumi Furusawa},
  journal={Journal of Dental Research},
  pages={504 - 509}
Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time reverse-transcription polymerase chain-reaction. Phosphatase activity and extracellular matrix mineralization were also determined. The role of Poly(P) was assessed in a beagle dog… 

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