Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks

@article{Shimada2008Ino80CR,
  title={Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks},
  author={Kenji Shimada and Y. Poudjodmj Oma and Thomas Schleker and Kazuto Kugou and Kunihiro Ohta and Masahiko Harata and Susan M. Gasser},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={566-575}
}
BACKGROUND Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires actin-related proteins, Arp4, Arp5 and Arp8, as well as two RuvB-like DNA helicase subunits. Budding yeast mutants deficient for Ino80 function are not only hypersensitive to reagents that induce DNA… CONTINUE READING