Innovative trial designs are practical solutions for improving the treatment of tuberculosis.

@article{Phillips2012InnovativeTD,
  title={Innovative trial designs are practical solutions for improving the treatment of tuberculosis.},
  author={P. Phillips and S. Gillespie and M. Boeree and N. Heinrich and R. Aarnoutse and T. McHugh and M. Pletschette and C. Lienhardt and R. Hafner and C. Mgone and Alimuddin Zumla and A. Nunn and M. Hoelscher},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={205 Suppl 2},
  pages={
          S250-7
        }
}
A growing number of new drugs for the treatment of tuberculosis are in clinical development. Confirmatory phase 3 trials are expensive and time-consuming and the question of whether one particular drug combination can be used to treat tuberculosis is less important from a public health perspective than the question of which are the shortest, simplest, most effective, and safest regimens. While preclinical and phase 1 studies provide some guidance in the selection of combinations for clinical… Expand

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