Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

@article{Kerkhof2006InnovativeMT,
  title={Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.},
  author={Esther G van de Kerkhof and Anna-Lena B. Ungell and A. Sj{\"o}berg and Marina H de Jager and Constanze Hilgendorf and Inge Anne Maria de Graaf and Geny M M Groothuis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 11},
  pages={1893-902}
}
Predictive in vitro methods to investigate drug metabolism in the human intestine using intact tissue are of high importance. Therefore, we studied the metabolic activity of human small intestinal and colon slices and compared it with the metabolic activity of the same human intestinal segments using the Ussing chamber technique. The metabolic activity was… CONTINUE READING