Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material.

@article{Backer2009InnovativeDA,
  title={Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material.},
  author={Benjamin De Backer and Benjamin Debrus and Pierre Lebrun and Laetitia Theunis and Nathalie G Dubois and Lies Decock and Alain Gaston Verstraete and Philippe Hubert and Corinne J Charlier},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 32},
  pages={4115-24}
}
GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Conversely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according… CONTINUE READING
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